Comprehensive research information for laboratory professionals
MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded within the 12S rRNA region of the mitochondrial genome. Unlike nuclear-encoded peptides, MOTS-c functions as an inter-organelle signaling molecule that communicates metabolic stress from mitochondria to the nucleus . Researchers study MOTS-c for its role in AMPK activation, glucose metabolism, and cellular stress adaptation. Its unique origin within the mitochondrial genome makes it a specialized tool for investigating mitochondrial-nuclear communication and metabolic regulation.