Comprehensive research information for laboratory professionals
Semax is a synthetic heptapeptide consisting of the ACTH(4–7) fragment (Met-Glu-His-Phe) with a C-terminal Pro-Gly-Pro tripeptide extension. Originally developed for acute stroke therapy research, Semax has no corticotropic activity but retains the parent molecule's neurotrophic properties . Researchers study Semax for its effects on brain-derived neurotrophic factor (BDNF) expression, neurotrophin receptor transcription, and neuroprotection in ischemic injury models. Its ability to selectively influence neurotrophin transcription in damaged tissue makes it a precise tool for studying neural repair mechanisms.