Comprehensive research information for laboratory professionals
TB-500 is a synthetic peptide fragment derived from thymosin beta-4 (Tβ4), a 43-amino-acid protein that is among the most abundant peptides in mammalian cells. The TB-500 fragment corresponds to the actin-binding region of Tβ4, specifically the LKKTET sequence that serves as the functional anchor for G-actin sequestration . Researchers study TB-500 to understand cytoskeletal dynamics, cell migration, and the upstream biology that enables wound healing and tissue remodeling. Unlike full-length Tβ4, the TB-500 fragment isolates the actin-binding mechanism, making it a precise tool for investigating cytoskeletal regulation without the confounding multi-pathway activity of the parent protein.