Comprehensive research information for laboratory professionals
Tesamorelin is a synthetic 44-amino-acid analog of human growth hormone-releasing hormone (GHRH). It features a trans-3-hexenoic acid modification on the tyrosine residue at position 1, which confers resistance to dipeptidyl peptidase-4 (DPP-4) degradation and extends its functional half-life . Researchers study tesamorelin for its effects on the hypothalamic-pituitary axis, pulsatile GH secretion, and downstream IGF-1 signaling. It is the only FDA-approved GHRH analog, making it a well-characterized reference compound for GH-axis research.