Selank Mechanism of Action

Selank modulates GABA receptor function through allosteric mechanisms rather than direct orthosteric binding. Research indicates that Selank affects the specific binding of GABA to GABAA receptors by altering receptor affinity for endogenous ligands . Microarray studies have identified significant changes in the mRNA levels of 84 genes related to GABAergic neurotransmission following Selank administration, including GABA receptor subunits, transporters, and ion channels . Additionally, Selank has been shown to influence dopamine and serotonin receptor expression, suggesting a complex, multi-system mechanism of action that extends beyond the GABAergic system alone.