Semax Research Highlights & Key Studies

Semax has been extensively studied in permanent middle cerebral artery occlusion (pMCAO) rat models, where researchers observed selective upregulation of neurotrophin transcription in ischemic cortex . The peptide has also been investigated in intact rat hippocampus, where rapid induction of Bdnf, Ngf, and TrkB expression was observed following administration. These findings establish Semax as a reference compound for researchers studying activity-dependent neurotrophin expression and neural repair mechanisms.